Growth Hormone Secretagogues
Growth Hormone Secretagogues: An Overview
Growth hormone–releasing peptides and analogues of GHRH stimulate endogenous pulsatile GH release through defined receptor pathways.
Compounds in this class act on either the GHRH receptor or the ghrelin/GHS receptor to stimulate pituitary GH release. The published literature spans endocrinology research and small clinical studies in adults with documented GH insufficiency.
Use outside well-defined medical indications is not supported by large outcome trials, and risks must be weighed against benefits with a qualified clinician.
Key takeaways
- Two main receptor pathways drive GH release.
- Most rigorous data is in diagnosed GH deficiency.
- Off-label use should be carefully supervised.
Source
PubMed Central (PMC)Educational only. Not medical advice. SEIVA protocols are prescribed only after physician review and telehealth consultation.